Predictive Significance of Ki-67 and Platelet Lymphocyte Ratio in Patients with Gastric Cancer Receiving Neoadjuvant FLOT Chemotherapy

OBJECTIVE We aimed to determine the predictive significance of Ki-67 and platelet lymphocyte ratio (PLR) in patients with gastric cancer (GC), who received fluorouracil, leucovorin, oxaliplatin, docetaxel (FLOT) as neoadjuvant chemotherapy (NAC). STUDY DESIGN Descriptive study. PLACE AND DURATION OF Department Medical Oncology, Faculty Medicine,  Ondokuz Mayis University, Samsun, Turkey from March 2016 January 2020. METHODOLOGY Seventy-five GC, FLOT treatment NAC were included Ki-67 and PLR, which examined pre-NAC aft-NAC, recorded. Associations between clinical-histopathological parameters disease-free survival (DFS) overall (OS) analysed using Kaplan-Meier curves. Cox-regression analysis was used assess their prognostic values. RESULTS There a statistically significant difference aft-NAC Ki-67, PLR values groups complete response, partial stable disease (p: 0.023, p: <0.001; 0.001, respectively). When grouped according changes, found terms OS (p< 0.001). High high associated shorter DFS 0.042, 0.049; 0.027, The OS, while 0.018,  p: In multivariate analysis, be an independent factor for OS. CONCLUSION have GC treated FLOT. is marker cancer. Key Words: FLOT, Gastric cancer, Platelet ratio.